IsoChemiX' Medicinal Chemistry function consists of talented and highly qualified scientists who have worked in projects covering complex natural product and multistage drug syntheses. There is considerable drug discovery experience with small molecules and biologicals across a broad range of synthetic and therapeutic areas, e.g. respiratory, inflammation, cancer, metabolic disease, CNS, infection, orphan diseases, and biological drug-target classes, e.g. kinases, GPCRs, ion channels, and antibody-drug conjugates.
Core synthetic competencies:
Contract synthesis of pro-drugs, full APIs and fragments in labelled heavy and light forms
Bespoke heavy and light analog synthesis viz Multi-stage synthesis of complex molecules, both light and heavy analogs
Chiral synthesis, chiral resolutions and chiral HPLC, both preparative and HPLC
Enzyme-mediated chemistry and related enantiomeric resolutions
Synthesis of small peptides and peptide mimetics
Parallel synthesis of lead-seeking arrays or focused libraries
Microwave assisted synthesis
Flow chemistry capability
In due course, integrated clinical discovery projects can be driven by IsoChemix aim to design and implement complete in vitro and in vivo screening cascades in combination with established medicinal chemistry expertise.
Please contact us to find out more or submit specific requests.